Contraindicated (1)pentobarbital will lessen the level or impact of cariprazine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is liable for the development and elimination of cariprazine's Energetic metabolites.pentobarbital will minimize the extent or outcome of ibuprofen by impacting hepatic enzyme CYP2C9/10 me